An easy solution from 2014!
Ever run into a virus that won’t let you open the desktop or go into Safe Mode? This solution will work on many of these viruses and not necessarily on all viruses or malware.
Hit – control-alt-delete key
Run the task manager
If you type or browse to explorer.exe, this may let you have the desktop. If NOT, have a flashdrive that has your tools (portable – malwarebytes, ADWCleaner, superantispyware or other tools and navigate to the tool – you may also have RKill on the drive to kill processes that are malicious) and navigate to the tool of your choice.
Run multiple tools until the malware is removed.