UPDATE – See note at the end of this article.
(This first option of repair the MBR can fix the Win32/Popureb.E virus)
Try Malwarebytes, Super AntiSpyware portable in Safe Mode First
You must boot the PC into repair mode, hitting F8 before windows starts and select:
Repair my Computer
Select the Command Prompt
The virus may have caused damage to your Master Boot Record (MBR) and Boot Configuration Data (BCD). :
Reboot your computer
Note: This should fix the MBR. You will then run your anti-virus again. Repairing an MBR can be risky.
Here’s a quick fix Dawn found! Kudos to her for finding a fix to save time -